The McBrayer Lab is focused on understanding how altered metabolism promotes the development of malignant brain tumors and simultaneously creates targetable, tumor-specific vulnerabilities. Specifically, we are interested in elucidating the diverse effects of highly recurrent hot-spot mutations in the genes encoding isocitrate dehydrogenase (IDH) enzymes, which represent the genetic hallmark of lower-grade gliomas and secondary glioblastomas. To study the molecular pathogenesis of IDH-mutant glioma, we use approaches rooted in molecular biology, biochemistry, genetics, and metabolism and employ a variety of research tools, including isogenic cell culture models, patient- and mouse-derived glioma neurosphere lines, patient-derived xenografts, and genetically-engineered mouse models. The long-term goals of the research program in the McBrayer Lab are: 1) to unveil fundamental mechanisms linking tumor-specific metabolic phenotypes with oncogenic epigenetic and transcriptomic programs, and 2) to devise new treatment strategies for brain tumor patients that exploit dependencies engendered by such phenotypes.
We are seeking a highly organized, enthusiastic, conscientious, and amiable individual for a research technician position in the newly founded McBrayer Lab. This position will provide substantial biomedical research experience and may yield co-authorship opportunities on scientific publications for a successful candidate.
Education: Bachelor’s degree in biology, biomedicine, biochemistry, chemistry, or related field
- Maintain and propagate transgenic mouse colonies with strong attention to detail and accuracy
- Prepare and submit tissue samples for genotyping analysis and interpret results
- Assist with surgeries and preclinical therapy trials involving mouse models of cancer
- Carry out focused molecular biology, biochemistry, or cell biology research projects under the guidance of senior laboratory personnel
- Diligently record details of daily work and outcomes of analyses
- Operate common laboratory equipment to provide technical assistance to laboratory personnel
- Prepare reagents and buffers to support biochemistry and molecular biology experiments
- Monitor inventory of consumables and assist with their ordering
To apply: submit resume here https://cri.utsw.edu/careers/staff-application/