Research Technician at UT Southwestern, McBrayer Lab (Dallas, TX)

The McBrayer Lab is focused on understanding how altered metabolism promotes the development of malignant brain tumors and simultaneously creates targetable, tumor-specific vulnerabilities. Specifically, we are interested in elucidating the diverse effects of highly recurrent hot-spot mutations in the genes encoding isocitrate dehydrogenase (IDH) enzymes, which represent the genetic hallmark of lower-grade gliomas and secondary glioblastomas. To study the molecular pathogenesis of IDH-mutant glioma, we use approaches rooted in molecular biology, biochemistry, genetics, and metabolism and employ a variety of research tools, including isogenic cell culture models, patient- and mouse-derived glioma neurosphere lines, patient-derived xenografts, and genetically-engineered mouse models. The long-term goals of the research program in the McBrayer Lab are: 1) to unveil fundamental mechanisms linking tumor-specific metabolic phenotypes with oncogenic epigenetic and transcriptomic programs, and 2) to devise new treatment strategies for brain tumor patients that exploit dependencies engendered by such phenotypes.

We are seeking a highly organized, enthusiastic, conscientious, and amiable individual for a research technician position in the newly founded McBrayer Lab. This position will provide substantial biomedical research experience and may yield co-authorship opportunities on scientific publications for a successful candidate.

Education: Bachelor’s degree in biology, biomedicine, biochemistry, chemistry, or related field

Job Duties:

  • Maintain and propagate transgenic mouse colonies with strong attention to detail and accuracy
  • Prepare and submit tissue samples for genotyping analysis and interpret results
  • Assist with surgeries and preclinical therapy trials involving mouse models of cancer
  • Carry out focused molecular biology, biochemistry, or cell biology research projects under the guidance of senior laboratory personnel
  • Diligently record details of daily work and outcomes of analyses
  • Operate common laboratory equipment to provide technical assistance to laboratory personnel
  • Prepare reagents and buffers to support biochemistry and molecular biology experiments
  • Monitor inventory of consumables and assist with their ordering

To apply: submit resume here https://cri.utsw.edu/careers/staff-application/