This is an exciting career opportunity to join the laboratory of Dr. Akiko Shimamura, MD PhD at Boston Children’s Hospital. Our laboratory is investigating the genetic basis of bone marrow failure and leukemia predisposition, and developing experimental models to gain mechanistic insights into disease pathogenesis and to develop novel therapies. We have identified genes causing marrow failure and leukemia, and have established a repository of clinically annotated samples that are used by our lab and shared with collaborators worldwide.
Our laboratory is located in the department of pediatric Hematology/Oncology at Harvard, which offers a strong team-based environment to conduct clinically-relevant research using a variety of genomic, molecular, biochemical, and cell-based technologies to model bone marrow failure and leukemia predisposition. Current projects in the lab involve genomic and transcriptomic studies, mammalian cell culture, and functional genomic screening in vitro and in vivo using RNA interference and CRISPR/Cas9. A project involving single cell genomic and transcriptomic analysis is in development.
In this position, you will have the opportunity to pursue a research project investigating the genetic and signaling pathways promoting bone marrow failure and leukemia. The ideal candidate will have prior experience with laboratory research (for example, a senior research thesis or summer research experience) in molecular biology, molecular cloning, mammalian cell culture, and gene transfer. Familiarity with computational biology is advantageous. We are seeking outstanding candidates with strong organizational and time management skills, the ability to work both independently and as part of a team, and strong communication skills.
Lab Website: http://www.shimamuralab.org/
Bachelor’s degree in a scientific field
Start date: Any time after July 1, 2019