Research Assistant Position at Harvard Medical School

by jsamarel

Research technician position, to start June-September 2017

A research technician position is available in the Howard Hughes laboratory of Dr. Stephen Elledge in the
Department of Genetics at Harvard Medical School. Under the supervision of MGH oncologist Dr.
Andrew Elia (, the candidate will assist in characterizing DNA damage response
pathways necessary for maintaining genomic stability and preventing cancer. These studies will help to
find new targets for the treatment of tumors with specific DNA repair defects. Laboratory is located in the
New Research Building at Harvard Medical School.

1. Characterize novel proteins involved in DNA damage signaling pathways using biochemistry and
cellular biology techniques (immunoprecipitation, Western blotting, immunofluorescence,
chromatography, flow cytometry, CRISPR, RNAi, and reporter gene assays).
2. Perform standard molecular biology techniques (cloning, site-directed mutagenesis, production
and purification of recombinant proteins).
3. Perform tissue culture work doing plasmid transfection, retroviral infection, lentiviral infection.
4. Assist in CRISPR functional genomic screen to identify genes required for the selective survival
of tumor cells with specific DNA repair defects.
5. Assist with quantitative mass spectrometry proteomics to identify novel post-translational
modifications involved in the DNA damage response.
6. Establish new and modify existing research techniques.
7. Starting some time during June-September 2017

• Bachelor degree in biology, biochemistry, chemistry, biotechnology or related science field
• 1-3 years experience in a molecular laboratory required.
• Self motivated, excited by science and medicine.
• Ability to perform as a team member.
• Independent thinker, takes ownership of work.
• Meticulous attention to detail
• Excellent organizational and analytical skills.
• Committed to producing accurate and high-quality work.

Please email your CV to Dr. Andrew Elia, M.D., Ph.D. at